LIST OF FIGURES VILIST OF TABLES VIIACKNOWLEDGEMENTS VIIIINTRODUCTION 1(7)TECHNOLOGICAL CHANGE AND THE PHARMACEUTICAL INDUSTRY 8(30)CARDIOVASCULAR DRUGS 38(24)ANTI-ASTHMATIC DRUGS 62(22)HISTAMINE H2 ANTAGONISTS 84(22)LHRH ANALOGUES 106(25)THREE CASE STUDIES OF PHARMACEUTICAL INNOVATION IN JAPAN 131(39)THE PROCESS OF DRUG DISCOVERY AND DEVELOPMENT 170(28)CONCLUSION 198(10)BIBLIO..