LIST OF FIGURES VI
LIST OF TABLES VII
ACKNOWLEDGEMENTS VIII
INTRODUCTION 1(7)
TECHNOLOGICAL CHANGE AND THE PHARMACEUTICAL INDUSTRY 8(30)
CARDIOVASCULAR DRUGS 38(24)
ANTI-ASTHMATIC DRUGS 62(22)
HISTAMINE H2 ANTAGONISTS 84(22)
LHRH ANALOGUES 106(25)
THREE CASE STUDIES OF PHARMACEUTICAL INNOVATION IN JAPAN 131(39)
THE PROCESS OF DRUG DISCOVERY AND DEVELOPMENT 170(28)
CONCLUSION 198(10)
BIBLIOGRAPHY 208(53)
INDEX 261
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