Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design toEnterprise-Wide Decisions, Volume 41, covers the following process systems engineering methodsand tools for the modernization of the pharmaceutical industry: computer-aided pharmaceuticalproduct design and pharmaceutical production processes design/synthesis; modeling andsimulation of the pharmaceutical processing unit operation, integrated flowsheets and applicationsfor design, analysis, risk assessment, sensitivity analysis, optimization, design space identificationand control system design; optimal operation, control and monitoring of pharmaceutical productionprocesses; enterprise-wide optimization and supply chain management for pharmaceuticalmanufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift,from traditional manufacturing mode to modernized mode, built on cutting edge technology andcomputer-aided methods and tools. Such shifts can benefit tremendously from the application ofmethods and tools of process systems engineering. Introduces Process System Engineering (PSE)methods and tools for discovering, developing and deploying greener, safer, cost-effective andefficient pharmaceutical production processes Includes a wide spectrum of case studies wheredifferent PSE tools and methods are used to improve various pharmaceutical production processeswith distinct final products Examines the future benefits and challenges for applying PSE methodsand tools to pharmaceutical manufacturing
1. New Product Discovery and Development for Pharmaceutical IndustryCatherine Azzaro-Pantel 2. The development of a pharmaceutical oral solid dosage formsRahamatullah Shaikh, Denise Croker, Donal O'Brien and Gavin Walker3. Innovative Process Development and Production Concepts for Small-molecule API ManufacturingJohn Woodley 4. Plantwide Technoeconomic Analysis and Separation Solvent Selection for Continuous Pharmaceutical Manufacturing: Ibuprofen, Artemisinin and DiphenhydramineDimitrios Gerogiorgis, Samir Diab and Hikaru Jolliffe5. Flowsheet Modeling of a Continuous Direct Compression ProcessSeongkyu Yoon 6. Plant-wide Dynamic Model for the Integrated Continuous Pharmaceutical Process: Design of the RecycleBrahim Benyahia 7. Advanced Multi-phase Hybrid Model Development of Fluidized Bed Wet Granulation ProcessesRohit Ramachandran, Ashutosh Tamrakar and Dheeraj R. Devarampally8. Global sensitivity, feasibility and flexibility analysis of continuous pharmaceutical manufacturing processesMarianthi Ierapetritou and Zilong Wang9. Crystallization process monitoring and control using process analytical technologyLevente Simon, Elena Simone?and Kaoutar Abbou Oucherif10. BioProcess Performance Monitoring using Multi-way Interval Partial Least SquaresJulian Morris, Jie Zhang and Shallon Stubbs11. Process Dynamics, and control of API manufacturing and purification processesMaitraye Sen, Ravendra Singh and Rohit Ramachandran12. PAT for pharmaceutical manufacturing process involving solid dosages formsAndr챕s David Rom찼n-Ospino, Carlos Alberto Ortega-Zuniga, Vanessa Cardenas and Ravendra Singh13. Model-based control system design and evaluation for continuous tablet manufac
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